The Sousse Archaeological Museum is an archaeological museum located in Sousse, Sousse Governorate, Tunisia.

The museum is housed in the Kasbah of Sousse's Medina, which was founded in the 11th century AD. It was established in 1951. The museum reopened its doors to the public in 2012, after the collections were rearranged and the edifice was renovated. It contains the second largest collection of mosaics in the world after that of the Bardo National Museum in the capital Tunis.